Towards Zettascale Connectomics(Aug 28th(Mon) 11:00~, E3-2 Wooribyul Seminar Room)

O Abstract:

Neuronal connectivity can be reconstructed from a 3D electron microscopy (EM) image of a brain volume. Connectomics is a modern reincarnation of neuroanatomy, aiming to densely reconstruct neurons, exhaustively detect synapses, and extract a comprehensive wiring diagram from a brain volume. For the past decade, deep learning has been extensively employed to reconstruct neural circuits from EM brain images. In this seminar, I will begin by introducing our deep learning-based computational pipeline for processing petascale EM image datasets in the field of connectomics. I will then spotlight automated reconstructions from both terascale and petascale EM image datasets from the fly and mouse brains. Notably, our pipeline’s automated reconstruction has been enhanced by 30 person-years of meticulous proofreading, culminating in the very first neuronal wiring diagram of an adult brain. I will discuss how connectomes will impact the future trajectory of neuroscience. To conclude, I will share insights on the rapidly evolving landscape of connectomics, with an ambitious vision of achieving zettascale reconstruction of the human brain.