Many of the assistive technologies and treatment systems currently available for movement disorders are not easy to use due to side effects, lack of efficacy, invasiveness, and bulkiness of the system. In addition, diseases are often misdiagnosed in their early stages or inefficiently treated due to the lack of efficient quantification tools. The goal of my research is to improve access to medical service for people with neurological disorders and physical disabilities, such as Parkinson’s disease, dementia, stroke, and spinal cord injuries and to provide efficient information to medical personnel. I aim to develop a wearable health monitoring systems and non-invasive neuromodulation by conducting Ability-based design (1) to quantitatively monitor/characterize their performance and (2) to augment/modulate their limited performance using a smart optimization algorithm. In this seminar, I will introduce my current research projects including the tongue-based assistive technology and its applications, the tremor monitor/diagnosis system for longitudinal home-based system, and the real-time neuromodulation for tremulous behaviors. And then, I will discuss how to approach the pathological behavior using wearable, mobile and non-invasive technologies to improve the quality of life.